Another cancer-killing virus … A ray of hope in treatment

Another cancer-killing virus ... A ray of hope in treatment


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The world has been struggling with Covid and, more recently, the monkey pox virus. Yet one of the major health problems of our time is cancer! Approximately 500,000 people are diagnosed with cancer each year and a third of them die.

The fact that there is no definitive cure for cancer and that its incidence is increasing day by day makes this disease a nightmare for people. However, the use of next-generation treatment methods that have emerged as a result of advances in medicine is relatively promising compared to traditional methods. One of these methods is “oncolytic virus” therapy…

In this treatment, it focuses on destroying only cancer cells without damaging healthy cells with viruses. This method, which is much more advantageous than other cancer treatments, has long sought solutions for many types of cancer, and viruses have been developed.

A NEW VIRUS WILL BE BORN AS MORE HOPE

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Finally ‘Vaxinia’ she called ‘CF33-hNIS’ the virus has caused excitement in the scientific world like a new oncolytic virus. It focuses on the fact that the virus, developed by researchers from the Australian company Imugene and the City of Hope National Medical Center in California, USA, can be effective against cancer cells.

Head of Studies at City of Hope National Medical Center Prof. DanengLi, “The time has come to further strengthen the power of immunotherapy, a type of treatment that allows the immune system to fight cancer cells. “We have found evidence that Vaxinia or CF33-hNIS has the potential to improve our cancer outcomes.” used phrases.

“May prevent new cancers”

Hacettepe University Vaccine Institute Faculty member doc. Dr. Sezer Okay “The Vaxinia study is very important in demonstrating the applicability of various methods for treating cancer with oncolytic viruses. Previous studies using oncolytic viruses hope that Vaxinia will also be successful. ” he said, adding:

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– Oncolytic viruses, also known as ‘tumor killing’, are natural or genetically modified viruses that can replicate in tumor cells and inhibit tumor growth without damaging healthy cells. These viruses are thought to be effective in treating cancer in recent years.

– Viruses work directly by lysing tumor cells. They activate the immune system against cancer in the body. Due to their multifunctional properties, they can be applied in the treatment of cancer, especially in combination with other therapies such as radiotherapy, chemotherapy and immunotherapy.

In addition, oncolytic viruses are very advantageous over other cancer treatments because they have the ability to kill only cancer cells without damaging healthy cells. For cancers that cannot be treated with surgery, it can be injected into the tumor to provide treatment. The effectiveness of oncolytic viruses can be increased by the addition of anti-cancer genes. Because these viruses activate the immune system, they can also prevent new cancers. For this reason, the latest study of Vaxinia is very valuable.

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The first information that the viruses destroyed the tumor dates back to 1912, when Italian doctor N. DePace observed that cervical cancer in a patient treated for rabies had subsided due to a dog bite. The first laboratory experiment was performed in 1922. A virus called ‘Vaccinia’ stops the development of tumors in mice.

The first information that the viruses destroyed the tumor dates back to 1912, when Italian doctor N. DePace observed that cervical cancer in a patient treated for rabies had subsided due to a dog bite. The first laboratory experiment was performed in 1922. A virus called ‘Vaccinia’ stops the development of tumors in mice.

THIS METHOD IS VERY IMPORTANT FOR SOLID CANCER SOLUTIONS

According to researchers from the City of Hope National Medical Center, previous studies have found that Vaxinia reduces cancerous tumors in preclinical laboratory experiments and animal models.

At the moment, the most important question waiting to be answered is: “How was Vaxinia developed and in which types of cancer can it be effective?”

He describes the new oncolytic virus as a promising development like many cancer studies, a specialist in biotechnology and virology Dr. Semih Tareen, “The developed virus called Vaxinia comes from the ‘POX virus’ family (smallpox virus)” said and shared important information:

Another cancer-killing virus ... A ray of hope in treatment

– Developed Vaxinia, or CF33-hNIS, is an artificial virus created by a combination of nine POX viruses. In this way, it can infect cancer cells more effectively. For this reason, it may enter cancer cells more dominantly than healthy cells. In fact, there are many advanced versions of the oncolytic POX virus called CF33. In 2019, the company began work on CF33.

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– There are also experiments in which they add a molecule called ‘PD-L1’. PD-L1 acts as a stem and inactivates T cells of the immune system. The results of this study have not yet been shared, but the process continues. But it should be emphasized: All these studies concern solid cancers and are very valuable.

In modern cancer therapies, we can achieve good success against liquid cancers, that is, blood cancer. But we are not doing very well yet for solid cancers. For example, a drug given during treatment cannot enter the tissues. Therefore, it seeks to develop such treatments. According to researchers, Vaxinia has been reported to shrink tumors of the colon, lung, breast, ovary and pancreas.

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PHASE-1 WORK STARTED
“If all goes well, a promising agent will show up.”

The first human application for Vaxinia took place on May 18, 2022. The Phase 1 clinical trial will be performed in 100 cancer patients with metastatic cancer (the cancer has spread to a site farther from the organ where the cancer originated) or advanced solid tumors at approximately 10 sites. in the United States and Australia. . The study is expected to last 24 months.

If the results of phase 1 are successful, phase 2 and phase 3 studies will be launched. So what will be considered in these studies?

Dr. Semih Tareen described the phases of the virus as follows:

– As a result of each phase of the work, certain goals are set. The first phase 1 Vaxinia studies have recently been launched. In general, the goals in the Phase 1 outcome are on the safety of treatment. The results of the effect of the virus are also examined. For example, they monitor certain molecules or whether cancers are gone. If good results are obtained in this respect, a phase 2 study will be launched.

– Phase 2 monitors more impacts. If it is effective, phase 3 will pass. In phase 3, the effect on much larger groups will be examined. If all goes well, he will need the approval of agencies such as the US Food and Drug Administration or the European Medicines Agency. This whole process will take a year.

The first proprietary oncolytic viral product was “Rigvir”, which was approved in Latvia in 2004. Rigvir, which was later registered in Georgia, Armenia and Uzbekistan, was used in the treatment of skin cancer, skin and subcutaneous topical treatment.

Another cancer-killing virus ... A ray of hope in treatment

The first proprietary oncolytic viral product was “Rigvir”, which was approved in Latvia in 2004. Rigvir, which was later registered in Georgia, Armenia and Uzbekistan, was used in the treatment of skin cancer, skin and subcutaneous topical treatment.

HOW WILL VAXINIA TREATMENT BE APPLIED?

Mind at the moment “If all goes well, how will Vaxinia treatment be applied? the question is coming. Will there be a vaccine, for example?

Dr. Semih Tareen “If the process continues positively, an approved treatment will appear, but it would be wrong to call it a vaccine.” He warned and added:

“Because it’s not a vaccine.” Here is a treatment that directly targets cancer. The purpose of the vaccine is to improve the immune system against certain diseases (cancer or infectious diseases). For this reason, it would not be right to call it a vaccine. “

Doc. Dr. Sezer Okay answered my question through the “T-Vec” example, which went down in 2015 as the first drug for oncolytic viral therapy by the US Food and Drug Administration (FDA):

– T-Vec, which received FDA approval in 2015, was reported to perform better than Phase 3 field applications. However, T-Vec is only used to treat malignant melanoma, the most aggressive and life-threatening skin cancer. Vaxinia is expected to be effective against various types of cancer.

– Therefore, it is premature to say whether it will be in the form of a vaccine or a drug. Vaxinia’s Phase-1 work has just begun, so it cannot be expected to enter the market in a short time. If the phase studies are successfully completed, we will obtain a promising means of treating various tumors.

Another cancer-killing virus ... A ray of hope in treatment

WHAT WILL BE THE BENEFITS OF USING ONCOLITIC VIRUSES AS VAXINIA IN THE TREATMENT OF CANCER?

Dr. Semih Tareen emphasized that there was a huge turnaround in cancer and that there was successful treatment, and shared the following information about the future of vaxina and oncolytic viruses:

– Important steps are being taken in cancer studies. Oncolytic viral therapy has also been considered a very important development for cancer in recent years. The increase in studies in this area is also gratifying … In particular, oncolytic virosis can come into play and offer solutions in cases where no other treatment can be applied.

– The treatment can be applied in combination with other treatments. For example, there are some monoclonal antibodies used in the treatment of cancer … Oncolytic viruses can be used with them. Thus, combination therapies can be performed.

– In short, very good options continue to be offered in the treatment of cancer. Many laboratories and companies are dealing with this issue. There are also many ongoing approved treatments. That’s why we should no longer be so hopeless about cancer.

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